Which transitional expression suggests a contrast between two ideas?

The transitional expression "in spite of" indicates a contrast because it introduces an idea that is unexpected or contrary to what might be anticipated. For example, if one statement suggests an expectation or a particular outcome, "in spite of" signifies that the following idea diverges from that expectation. This expression builds a sense of tension or contradiction between the two ideas being presented, highlighting the fact that circumstances are not aligned with the anticipated result.

In contrast, the other options do not serve this purpose. "In comparison" suggests similarity, "consequently" indicates a cause-and-effect relationship, and "in like manner" also implies similarity or agreement rather than contrast. Thus, "in spite of" is the appropriate choice for highlighting a contrast between two ideas.